NEONATOLOGY / RESEARCH PAPER
The incidence and risk factors of bronchopulmonary
dysplasia in extremely preterm infants included in the
Polish National Program for Respiratory Syncytial Virus
Prophylaxis
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1
NZOZ VM Care, Cracow, Poland
2
Department of Neonatology, Jagiellonian University Medical College, Cracow, Poland
Submission date: 2020-05-22
Final revision date: 2020-08-23
Acceptance date: 2020-09-07
Online publication date: 2021-03-21
Corresponding author
Róża Borecka
Pediatric Unit, Independent Public Health Care Center, ul. Szpitalna 2, 32-400, Myślenice, Poland
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Bronchopulmonary dysplasia (BPD) is a chronic lung disease
diagnosed in premature infants, which may cause severe respiratory failure
due to respiratory syncytial virus (RSV) infection. The aim of this study was
to assess the incidence and severity of BPD in infants born before 28 weeks
of gestational age (GA) enrolled into the Polish National Program for RSV
Prophylaxis (PNPRSVP).
Material and methods:
A retrospective analysis of data on children born
in 2013 included in a prophylaxis program during the seasons 2012–2013
and 2013–2014. The following data were evaluated: the need for oxygen
therapy for at least 28 days and the need for oxygen therapy at 36 weeks of
postmenstrual age (PMA).
Results:
The analysis was carried out in a group of 603 children, who constituted 87.7% of the population entitled to prophylactic administration of
palivizumab. BPD was diagnosed in 80.9% of extremely preterm infants;
however, in 70.7% of cases the disease was mild. The risk factors for the
development of BPD were GA, birth weight and birth weight below the 10th
centile for GA. During the program, the median number of doses received
was 5 (range 1–5), and 82.3% of children received all of the expected doses.
Conclusions:
Although the incidence of BPD in extremely preterm infants
was high, mainly its mild form was recognized. Monitoring of the incidence
of the disease and identifying the risk factors can be carried out effectively
based on long-term data collected during the PNPRSVP.