Current issue
Archive
Manuscripts accepted
About the Journal
Editorial office
Editorial board
Abstracting and indexing
Subscription
Contact
Ethical standards and procedures
Most read articles
Instructions for authors
Article Processing Charge (APC)
Regulations of paying article processing charge (APC)
NEUROSURGERY / RESEARCH LETTER
Sanguiin inhibits cerebral hemorrhage in rats by protecting the blood-brain barrier
1
Department of Neurosurgery, The Dalian School of Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China
2
Department of Neurosurgery, Shanghai Pudong New Area People’s Hospital, Shanghai, China
3
Department of Radiology, Shanghai Putuo Central Hospital, Shanghai, China
4
Department of Neurosurgery, The Yangzhou School of Clinical Medicine, Dalian Medical College, Yangzhou, Jiangsu, China
These authors had equal contribution to this work
Submission date: 2024-08-02
Final revision date: 2024-08-23
Acceptance date: 2024-08-28
Online publication date: 2024-08-31
Publication date: 2024-08-04
Corresponding author
Arch Med Sci 2024;20(4):1345-1348
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The aim of the study was to observe the effect of Sanguiin on cerebral edema and behavior in a rat cerebral hemorrhage model.
Material and methods:
A rat collagenase-induced cerebral hemorrhage model was established to detect the effects of drugs on brain edema.
Results:
Through magnetic resonance imaging (MRI) analysis and brain weight content (BWC) determination, it was found that Sanguiin could significantly reduce the brain swelling index and BWC of the affected hemisphere after cerebral hemorrhage.
Conclusions:
Sanguiin can significantly improve the neurological deficits in rats with cerebral hemorrhage, and down-regulate the expression of MMP-9 after cerebral hemorrhage, suggesting that Sanguiin has a certain protective effect on the blood-brain barrier after cerebral hemorrhage.
The aim of the study was to observe the effect of Sanguiin on cerebral edema and behavior in a rat cerebral hemorrhage model.
Material and methods:
A rat collagenase-induced cerebral hemorrhage model was established to detect the effects of drugs on brain edema.
Results:
Through magnetic resonance imaging (MRI) analysis and brain weight content (BWC) determination, it was found that Sanguiin could significantly reduce the brain swelling index and BWC of the affected hemisphere after cerebral hemorrhage.
Conclusions:
Sanguiin can significantly improve the neurological deficits in rats with cerebral hemorrhage, and down-regulate the expression of MMP-9 after cerebral hemorrhage, suggesting that Sanguiin has a certain protective effect on the blood-brain barrier after cerebral hemorrhage.
REFERENCES (20)
1.
Han JH, Kim M, Choi HJ, et al. The oral administration of sanguisorba officinalis extract improves physical performance through LDHA modulation. Molecules 2021; 26: 1579.
2.
Jiang N, Li H, Sun Y, et al. Network pharmacology and pharmacological evaluation reveals the mechanism of the sanguisorba officinalis in suppressing hepatocellular carcinoma. Front Pharmacol 2021; 12: 618522.
3.
Ziai WC, Carhuapoma JR. Intracerebral hemorrhage. Continuum (Minneap Minn) 2018; 24: 1603-22.
4.
Zhu H, Wang Z, Yu J, et al. Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage. Prog Neurobiol 2019; 178: 101610.
5.
Volbers B, Giede-Jeppe A, Gerner ST, et al. Peak perihemorrhagic edema correlates with functional outcome in intracerebral hemorrhage. Neurology 2018; 90: e1005-12.
6.
Sprugel MI, Huttner HB. Intracerebral hemorrhage: hot topics. Nervenarzt 2019; 90: 987-94.
7.
Shao A, Zhu Z, Li L, Zhang S, Zhang J. Emerging therapeutic targets associated with the immune system in patients with intracerebral hemorrhage (ich): from mechanisms to translation. EBioMedicine 2019; 45: 615-23.
8.
Bonaventura A, Liberale L, Carbone F, et al. The pathophysiological role of neutrophil extracellular traps in inflammatory diseases. Thromb Haemost 2018; 118: 6-27.
9.
Ducroux C, Di Meglio L, Loyau S, et al. Thrombus neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke. Stroke 2018; 49: 754-7.
10.
Yao Z, Hu X, You C, He M. Effect and feasibility of endoscopic surgery in spontaneous intracerebral hemorrhage: a systematic review and meta-analysis. World Neurosurg 2018; 113: 348-56.
11.
Kellner CP, Chartrain AG, Nistal DA, et al. The stereotactic intracerebral hemorrhage underwater blood aspiration (scuba) technique for minimally invasive endoscopic intracerebral hemorrhage evacuation. J Neurointerv Surg 2018; 10: 771-6.
12.
Bhatia K, Hepburn M, Ziu E, Siddiq F, Qureshi AI. Modern approaches to evacuating intracerebral hemorrhage. Curr Cardiol Rep 2018; 20: 132.
13.
Hanley DF, Thompson RE, Rosenblum M, et al. Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral hemorrhage evacuation (mistie iii): a randomized, controlled, open-label, blinded endpoint phase 3 trial. Lancet 2019; 393: 1021-32.
14.
Hu S, Hua Y, Keep RF, Feng H, Xi G. Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets. Exp Neurol 2019; 318: 244-50.
15.
Nomura K, Miyashita T, Yamamoto Y, et al. Citrullinated histone h3: early biomarker of neutrophil extracellular traps in septic liver damage. J Surg Res 2019; 234: 132-8.
16.
Jha RM, Kochanek PM, Simard JM. Pathophysiology and treatment of cerebral edema in traumatic brain injury. Neuropharmacology 2019; 145: 230-46.
17.
Ironside N, Chen CJ, Ding D, Mayer SA, Connolly ES Jr. Perihematomal edema after spontaneous intracerebral hemorrhage. Stroke 2019; 50: 1626-33.
18.
Jinshi L, Cong Y, Liang S, Dabin R, Ping Z. Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke. Arch Med Sci 2024; 20: 321-5.
19.
Li J, Li FS, He B, Yu C, Zheng P. Shared immune metabolic reprogramming between COVID-10 patients in the intensive care unit and ischemic stroke: a pilot study. Arch Med Sci 2023; 19: 1904-8.
20.
Zhu SL, Tang JH, Lan L, Su F. Inhibition of miR-34a ameliorates cerebral ischemia/reperfusion injury by targeting brain-derived neurotrophic factor. Arch Med Sci (epub of print). Doi.org/10.5114/aoms/143303.
Share
RELATED ARTICLE
| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
