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Role of nutrition and healthy lifestyle, for individuals in primary prevention: recent data, gaps in evidence and future directions
Pierre Sabouret
10,11
1
Catholic University of the Sacred Heart, Rome, Italy
2
Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy
3
Prevention Center ELLASANTE, Paris, France
4
Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy
5
Delta Clinic, Rosario, Argentina
6
Service de Cardiologie, Centre Hospitalier Régional Universitaire et Faculté de Médecine de Tours, Tours, France
7
EA4245, Transplantation Immunité Inflammation, Université de Tours, Tours, France
8
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
9
Mediterranea Cardiocentro, Napoli, Italy
10
Heart Institute, Boulevard de l’Hôpital, ACTION Study Group-CHU Pitié-Salpétrière Paris, France
11
Collège National des Cardiologues Français (CNCF), Paris, France
Submission date: 2024-01-27
Final revision date: 2024-04-11
Acceptance date: 2024-04-23
Online publication date: 2024-04-30
Corresponding author
Marco Bernardi
Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy
Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy
KEYWORDS
TOPICS
ABSTRACT
All recent guidelines on cardiovascular prevention have highlighted the role of a healthy diet and lifestyle advocating an holistic approach to reduce the cardiovascular burden among the population. Despite these efforts, registries have reported that only a minority of healthcare professionals provide advice on diet and lifestyle, and, in most cases, counseling is suboptimal for several reasons. Cardiovascular benefits linked to lifestyle and nutrition seem to be underestimated by many patients and doctors. This overview aims to summarize well-established benefits related to lifestyle and nutrition, discuss the current debates in this field in order to improve awareness among the medical community and promote better implementation of non-pharmaceutical measures to prevent the occurrence of atherothrombotic events, by reducing cardiovascular risk factors such as hypertension, diabetes, dyslipidemia, and obesity.
REFERENCES (138)
1.
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736-88.
2.
Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2021; 42: 3227-337.
3.
Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2019; 140: e596-646.
4.
Bielecka-Dabrowa A, Lewek J, Sakowicz A, et al. Effects of implementing personalized health education in ambulatory care on cardiovascular risk factors, compliance and satisfaction with treatment. J Pers Med 2022; 12: 1583.
5.
Dobrowolski P, Prejbisz A, Kuryłowicz A, et al. Metabolic syndrome – a new definition and management guidelines: A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, “Club 30” Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons. Arch Med Sci 2022; 18: 1133-56.
6.
Neufeld LM, Hendriks S, Hugas M. Healthy diet: a definition for the United Nations Food Systems Summit 2021. In: Science and Innovations for Food Systems Transformation. von Braun J, Afsana K, Fresco LO, Hassan MHA, eds. Cham: Springer International Publishing 2023: 21-30.
7.
Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser 2003; 916: i-viii, 1-149, backcover.
8.
Sikand G, Severson T. Corrigendum to “Top 10 dietary strategies for atherosclerotic cardiovascular risk reduction’’ [American Journal of Preventive Cardiology, Volume 4, 2020, Pages 1-12]. Am J Prev Cardiol 2021; 6: 100174.
9.
Davis C, Bryan J, Hodgson J, Murphy K. Definition of the Mediterranean diet; a literature review. Nutrients 2015; 7: 9139-53.
10.
Menotti A, Kromhout D, Blackburn H, Fidanza F, Buzina R, Nissinen A. Food intake patterns and 25-year mortality from coronary heart disease: cross-cultural correlations in the Seven Countries Study. The Seven Countries Study Research Group. Eur J Epidemiol 1999; 15: 507-15.
11.
Rizzo M, Colletti A, Penson PE, et al. Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): a position paper from the International Lipid Expert Panel (ILEP). Pharmacol Res 2023; 189: 106679.
12.
Martinez-Gonzalez MA, Salas-Salvado J, Estruch R, Corella D, Fito M, Ros E, Predimed I. Benefits of the Mediterranean diet: insights from the PREDIMED Study. Prog Cardiovasc Dis 2015; 58: 50-60.
13.
Richard JL. [Coronary risk factors. The French paradox]. Arch Mal Coeur Vaiss 1987; 80 Spec No: 17-21.
14.
de Lorgeril M, Salen P, Paillard F, Laporte F, Boucher F, de Leiris J. Mediterranean diet and the French paradox: two distinct biogeographic concepts for one consolidated scientific theory on the role of nutrition in coronary heart disease. Cardiovasc Res 2002; 54: 503-15.
15.
Tong TY, Wareham NJ, Khaw KT, Imamura F, Forouhi NG. Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study. BMC Med 2016; 14: 135.
16.
Tognon G, Nilsson LM, Lissner L, et al. The Mediterranean diet score and mortality are inversely associated in adults living in the subarctic region. J Nutr 2012; 142: 1547-53.
17.
Tognon G, Lissner L, Saebye D, Walker KZ, Heitmann BL. The Mediterranean diet in relation to mortality and CVD: a Danish cohort study. Br J Nutr 2014; 111: 151-9.
18.
Hoevenaar-Blom MP, Spijkerman AM, Boshuizen HC, Boer JM, Kromhout D, Verschuren WM. Effect of using repeated measurements of a Mediterranean style diet on the strength of the association with cardiovascular disease during 12 years: the Doetinchem Cohort Study. Eur J Nutr 2014; 53: 1209-15.
19.
Salas-Salvado J, Garcia-Arellano A, Estruch R, et al. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr 2008; 62: 651-9.
20.
Llorente-Cortes V, Estruch R, Mena MP, et al. Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis 2010; 208: 442-50.
21.
Martin-Pelaez S, Fito M, Castaner O. Mediterranean diet effects on type 2 diabetes prevention, disease progression, and related mechanisms. A review. Nutrients 2020; 12: 2236.
22.
Sanches Machado d’Almeida K, Ronchi Spillere S, Zuchinali P, Correa Souza G. Mediterranean diet and other dietary patterns in primary prevention of heart failure and changes in cardiac function markers: a systematic review. Nutrients 2018; 10: 58.
23.
Cacciatore S, Calvani R, Marzetti E, et al. Low adherence to mediterranean diet is associated with probable sarcopenia in community-dwelling older adults: results from the Longevity Check-Up (Lookup) 7+ Project. Nutrients 2023; 15: 1026.
24.
Couto E, Boffetta P, Lagiou P, et al. Mediterranean dietary pattern and cancer risk in the EPIC cohort. Br J Cancer 2011; 104: 1493-9.
25.
Kris-Etherton P, Eckel RH, Howard BV, St Jeor S, Bazzarre TL. AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. Circulation 2001; 103: 1823-5.
26.
Chiavaroli L, Viguiliouk E, Nishi SK, et al. DASH Dietary Pattern and Cardiometabolic Outcomes: an umbrella review of systematic reviews and meta-analyses. Nutrients 2019; 11: 338.
27.
Levitan EB, Wolk A, Mittleman MA. Consistency with the DASH diet and incidence of heart failure. Arch Intern Med 2009; 169: 851-7.
28.
Nguyen HT, Bertoni AG, Nettleton JA, Bluemke DA, Levitan EB, Burke GL. DASH eating pattern is associated with favorable left ventricular function in the multi-ethnic study of atherosclerosis. J Am Coll Nutr 2012; 31: 401-7.
29.
Filippou CD, Tsioufis CP, Thomopoulos CG, et al. Dietary approaches to stop hypertension (DASH) diet and blood pressure reduction in adults with and without hypertension: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr 2020; 11: 1150-60.
30.
Dinu M, Abbate R, Gensini GF, Casini A, Sofi F. Vegetarian, vegan diets and multiple health outcomes: a systematic review with meta-analysis of observational studies. Crit Rev Food Sci Nutr 2017; 57: 3640-9.
31.
Satija A, Hu FB. Plant-based diets and cardiovascular health. Trends Cardiovasc Med 2018; 28: 437-41.
32.
Gibbs J, Gaskin E, Ji C, Miller MA, Cappuccio FP. The effect of plant-based dietary patterns on blood pressure: a systematic review and meta-analysis of controlled intervention trials. J Hypertens 2021; 39: 23-37.
33.
Calder PC. Functional roles of fatty acids and their effects on human health. JPEN J Parenter Enteral Nutr 2015; 39: 18s-32s.
34.
Jain AP, Aggarwal KK, Zhang PY. Omega-3 fatty acids and cardiovascular disease. Eur Rev Med Pharmacol Sci 2015; 19: 441-5.
35.
Islam MA, Amin MN, Siddiqui SA, Hossain MP, Sultana F, Kabir MR. Trans fatty acids and lipid profile: a serious risk factor to cardiovascular disease, cancer and diabetes. Diabetes Metab Syndr 2019; 13: 1643-7.
36.
Sacks FM, Lichtenstein AH, Wu JHY, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation 2017; 136: e1-23.
37.
Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr 2010; 91: 502-9.
38.
Clifton PM, Keogh JB. A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease. Nutr Metab Cardiovasc Dis 2017; 27: 1060-80.
39.
Ludwig DS, Ebbeling CB. The carbohydrate-insulin model of obesity: beyond “calories in, calories out”. JAMA Intern Med 2018; 178: 1098-103.
40.
Hall KD. A review of the carbohydrate-insulin model of obesity. Eur J Clin Nutr 2017; 71: 323-6.
41.
Dashti HM, Mathew TC, Al-Zaid NS. Efficacy of low-carbohydrate ketogenic diet in the treatment of type 2 diabetes. Med Princ Pract 2021; 30: 223-35.
42.
Seidelmann SB, Claggett B, Cheng S, et al. Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. Lancet Public Health 2018; 3: e419-28.
43.
Miller V, Mente A, Dehghan M, et al. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study. Lancet 2017; 390: 2037-49.
44.
Sievenpiper JL. Low-carbohydrate diets and cardiometabolic health: the importance of carbohydrate quality over quantity. Nutr Rev 2020; 78: 69-77.
45.
Clayton ZS, Fusco E, Kern M. Egg consumption and heart health: a review. Nutrition 2017; 37: 79-85.
46.
Miller CA, Corbin KD, da Costa KA, et al. Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Am J Clin Nutr 2014; 100: 778-86.
47.
Mutungi G, Ratliff J, Puglisi M, et al. Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet. J Nutr 2008; 138: 272-6.
48.
Blesso CN, Andersen CJ, Barona J, Volk B, Volek JS, Fernandez ML. Effects of carbohydrate restriction and dietary cholesterol provided by eggs on clinical risk factors in metabolic syndrome. J Clin Lipidol 2013; 7: 463-71.
49.
Onyszkiewicz M, Jaworska K, Ufnal M. Short chain fatty acids and methylamines produced by gut microbiota as mediators and markers in the circulatory system. Exp Biol Med (Maywood) 2020; 245: 166-75.
50.
Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013; 19: 576-85.
51.
Oellgaard J, Winther SA, Hansen TS, Rossing P, von Scholten BJ. Trimethylamine N-oxide (TMAO) as a new potential therapeutic target for insulin resistance and cancer. Curr Pharm Des 2017; 23: 3699-712.
52.
Jing L, Zhang H, Xiang Q, et al. Targeting trimethylamine N-oxide: a new therapeutic strategy for alleviating atherosclerosis. Front Cardiovasc Med 2022; 9: 864600.
53.
van Dam RM, Hu FB, Willett WC. Coffee, caffeine, and health. N Engl J Med 2020; 383: 369-78.
54.
Turnbull D, Rodricks JV, Mariano GF, Chowdhury F. Caffeine and cardiovascular health. Regul Toxicol Pharmacol 2017; 89: 165-85.
55.
Del Giorno R, Scanzio S, De Napoli E, et al. Habitual coffee and caffeinated beverages consumption is inversely associated with arterial stiffness and central and peripheral blood pressure. Int J Food Sci Nutr 2022; 73: 106-15.
56.
Mesas AE, Leon-Muñoz LM, Rodriguez-Artalejo F, Lopez-Garcia E. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am J Clin Nutr 2011; 94: 1113-26.
57.
Konstantinidi M, Koutelidakis AE. Functional foods and bioactive compounds: a review of its possible role on weight management and obesity’s metabolic consequences. Medicines (Basel) 2019; 6: 94.
58.
Nordestgaard AT, Thomsen M, Nordestgaard BG. Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study. Int J Epidemiol 2015; 44: 551-65.
59.
Akash MS, Rehman K, Chen S. Effects of coffee on type 2 diabetes mellitus. Nutrition 2014; 30: 755-63.
60.
Cai L, Ma D, Zhang Y, Liu Z, Wang P. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur J Clin Nutr 2012; 66: 872-7.
61.
Bak AA, Grobbee DE. The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 1989; 321: 1432-7. 3.
62.
Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB. Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation 2014; 129: 643-59.
63.
Stevens LM, Linstead E, Hall JL, Kao DP. Association between coffee intake and incident heart failure risk: a machine learning analysis of the FHS, the ARIC Study, and the CHS. Circ Heart Fail 2021; 14: e006799.
64.
Voskoboinik A, Kalman JM, Kistler PM. Caffeine and arrhythmias: time to grind the data. JACC Clin Electrophysiol 2018; 4: 425-32.
65.
Joris PJ, Mensink RP, Adam TC, Liu TT. Cerebral blood flow measurements in adults: a review on the effects of dietary factors and exercise. Nutrients 2018; 10: 530.
66.
Voskoboinik A, Koh Y, Kistler PM. Cardiovascular effects of caffeinated beverages. Trends Cardiovasc Med 2019; 29: 345-50.
67.
Chieng D, Kistler PM. Coffee and tea on cardiovascular disease (CVD) prevention. Trends Cardiovasc Med 2022; 32: 399-405. 4.
68.
Bitok E, Sabate J. Nuts and cardiovascular disease. Prog Cardiovasc Dis 2018; 61: 33-7.
69.
Ros E, Mataix J. Fatty acid composition of nuts--implications for cardiovascular health. Br J Nutr 2006; 96 Suppl 2: S29-35.
70.
Fraser GE, Sabate J, Beeson WL, Strahan TM. A possible protective effect of nut consumption on risk of coronary heart disease. The Adventist Health Study. Arch Intern Med 1992; 152: 1416-24.
71.
Hu FB, Stampfer MJ, Manson JE, et al. Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ 1998; 317: 1341-5.
72.
Kelly JH Jr, Sabate J. Nuts and coronary heart disease: an epidemiological perspective. Br J Nutr 2006; 96 Suppl 2: S61-7.
73.
Martinez-Gonzalez MA, Corella D, Salas-Salvado J, et al. Cohort profile: design and methods of the PREDIMED study. Int J Epidemiol 2012; 41: 377-85.
74.
Sabate J, Oda K, Ros E. Nut consumption and blood lipid levels: a pooled analysis of 25 intervention trials. Arch Intern Med 2010; 170: 821-7.
75.
Berryman CE, Preston AG, Karmally W, Deckelbaum RJ, Kris-Etherton PM. Effects of almond consumption on the reduction of LDL-cholesterol: a discussion of potential mechanisms and future research directions. Nutr Rev 2011; 69: 171-85.
76.
Kris-Etherton PM, Hu FB, Ros E, Sabate J. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr 2008; 138: 1746S-51S.
77.
Xiao Y, Huang W, Peng C, et al. Effect of nut consumption on vascular endothelial function: a systematic review and meta-analysis of randomized controlled trials. Clin Nutr 2018; 37: 831-9.
78.
Watanabe Y, Tatsuno I. Prevention of cardiovascular events with omega-3 polyunsaturated fatty acids and the mechanism involved. J Atheroscler Thromb 2020; 27: 183-98.
79.
Hirai A, Hamazaki T, Terano T, et al. Eicosapentaenoic acid and platelet function in Japanese. Lancet 1980; 2: 1132-3.
80.
Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 2002; 20: 1493-9.
81.
Robinson JG, Stone NJ. Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am J Cardiol 2006; 98: 39i-49i.
82.
Harris WS, Bulchandani D. Why do omega-3 fatty acids lower serum triglycerides? Curr Opin Lipidol 2006; 17: 387-93.
83.
Soliman GA. Dietary fiber, atherosclerosis, and cardiovascular disease. Nutrients 2019; 11: 1155.
84.
Wright RS, Anderson JW, Bridges SR. Propionate inhibits hepatocyte lipid synthesis. Proc Soc Exp Biol Med 1990; 195: 26-9.
85.
Threapleton DE, Greenwood DC, Evans CE, et al. Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 2013; 347: f6879.
86.
Buil-Cosiales P, Zazpe I, Toledo E, et al. Fiber intake and all-cause mortality in the Prevencion con Dieta Mediterranea (PREDIMED) study. Am J Clin Nutr 2014; 100: 1498-507. 7.
87.
Whelton SP, Hyre AD, Pedersen B, Yi Y, Whelton PK, He J. Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J Hypertens 2005; 23: 475-81.
88.
Delzenne NM, Cani PD. A place for dietary fibre in the management of the metabolic syndrome. Curr Opin Clin Nutr Metab Care 2005; 8: 636-40.
89.
Anderson JW, Baird P, Davis RH Jr, et al. Health benefits of dietary fiber. Nutr Rev 2009; 67: 188-205.
90.
Michos ED, Cainzos-Achirica M, Heravi AS, Appel LJ. Vitamin D, calcium supplements, and implications for cardiovascular health: JACC Focus Seminar. J Am Coll Cardiol 2021; 77: 437-49.
91.
Gunta SS, Thadhani RI, Mak RH. The effect of vitamin D status on risk factors for cardiovascular disease. Nat Rev Nephrol 2013; 9: 337-47.
92.
Robinson-Cohen C, Hoofnagle AN, Ix JH, et al. Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events. JAMA 2013; 310: 179-88.
93.
Lutsey PL, Michos ED, Misialek JR, et al. Race and vitamin D binding protein gene polymorphisms modify the association of 25-hydroxyvitamin D and incident heart failure: the ARIC (Atherosclerosis Risk in Communities) Study. JACC Heart Fail 2015; 3: 347-56.
94.
Tice JA, Halalau A, Burke H. Vitamin D does not prevent cancer or cardiovascular disease: the VITAL Trial. Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D’Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE (2019) Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med 380 (1):33-44. J Gen Intern Med 2020; doi: 10.1007/s11606-020-05648-x.
95.
Barbarawi M, Kheiri B, Zayed Y, et al. Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals in 21 randomized clinical trials: a meta-analysis. JAMA Cardiol 2019; 4: 765-76.
96.
Neale RE, Baxter C, Romero BD, et al. The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality. Lancet Diabetes Endocrinol 2022; 10: 120-8.
97.
Thompson B, Waterhouse M, English DR, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial. BMJ 2023; 381: e075230.
98.
Xiao Q, Murphy RA, Houston DK, Harris TB, Chow WH, Park Y. Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med 2013; 173: 639-46.
99.
Yang C, Shi X, Xia H, et al. The Evidence and controversy between dietary calcium intake and calcium supplementation and the risk of cardiovascular disease: a systematic review and meta-analysis of cohort studies and randomized controlled trials. J Am Coll Nutr 2020; 39: 352-70.
100.
Reid IR, Bolland MJ, Avenell A, Grey A. Cardiovascular effects of calcium supplementation. Osteoporos Int 2011; 22: 1649-58.
101.
Danziger J, Zeidel ML. Osmotic homeostasis. Clin J Am Soc Nephrol 2015; 10: 852-62.
102.
Firestone GL, Giampaolo JR, O’Keeffe BA. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 2003; 13: 1-12.
103.
Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging 2018; 13: 757-72.
104.
Blomhoff R. Dietary antioxidants and cardiovascular disease. Curr Opin Lipidol 2005; 16: 47-54.
105.
Aune D. Plant foods, antioxidant biomarkers, and the risk of cardiovascular disease, cancer, and mortality: a review of the evidence. Adv Nutr 2019; 10: S404-21.
106.
Jenkins DJA, Spence JD, Giovannucci EL, et al. Supplemental vitamins and minerals for CVD prevention and treatment. J Am Coll Cardiol 2018; 71: 2570-84.
107.
Macready AL, George TW, Chong MF, et al. Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease--FLAVURS: a randomized controlled trial. Am J Clin Nutr 2014; 99: 479-89.
108.
Katcher HI, Legro RS, Kunselman AR, et al. The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome. Am J Clin Nutr 2008; 87: 79-90.
109.
Nani A, Murtaza B, Sayed Khan A, Khan NA, Hichami A. Antioxidant and anti-inflammatory potential of polyphenols contained in mediterranean diet in obesity: molecular mechanisms. Molecules 2021; 26: 985.
110.
Zuo X, Tian C, Zhao N, et al. Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway. BMC Res Notes 2014; 7: 120.
111.
Rechner AR, Wagner E, Van Buren L, Van De Put F, Wiseman S, Rice-Evans CA. Black tea represents a major source of dietary phenolics among regular tea drinkers. Free Radic Res 2002; 36: 1127-35.
112.
Marketou ME, Maragkoudakis S, Anastasiou I, et al. Salt-induced effects on microvascular function: a critical factor in hypertension mediated organ damage. J Clin Hypertens (Greenwich) 2019; 21: 749-57.
113.
Harvey A, Montezano AC, Lopes RA, Rios F, Touyz RM. Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Can J Cardiol 2016; 32: 659-68.
114.
Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017-2018. NCHS Data Brief 2020:1-8.
115.
Jousilahti P, Tuomilehto J, Vartiainen E, Pekkanen J, Puska P. Body weight, cardiovascular risk factors, and coronary mortality. 15-year follow-up of middle-aged men and women in eastern Finland. Circulation 1996; 93: 1372-9.
116.
Parto P, Lavie CJ. Obesity and cardiovascular diseases. Curr Probl Cardiol 2017; 42: 376-94.
117.
Tchkonia T, Thomou T, Zhu Y, et al. Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab 2013; 17: 644-56.
118.
Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med 2017; 376: 254-66.
119.
Piercy KL, Troiano RP, Ballard RM, et al. The physical activity guidelines for Americans. JAMA 2018; 320: 2020-8.
120.
Swift DL, McGee JE, Earnest CP, Carlisle E, Nygard M, Johannsen NM. The effects of exercise and physical activity on weight loss and maintenance. Prog Cardiovasc Dis 2018; 61: 206-13.
121.
Elagizi A, Kachur S, Carbone S, Lavie CJ, Blair SN. A review of obesity, physical activity, and cardiovascular disease. Curr Obes Rep 2020; 9: 571-81.
122.
Banach M, Lewek J, Surma S, et al. The association between daily step count and all-cause and cardiovascular mortality: a meta-analysis. Eur J Prev Cardiol 2023; 30: 1975-85.
123.
Bey L, Hamilton MT. Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity. J Physiol 2003; 551: 673-82.
124.
Joseph AM, Adhihetty PJ, Buford TW, et al. The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging Cell 2012; 11: 801-9.
125.
Katzmarzyk PT, Church TS, Craig CL, Bouchard C. Sitting time and mortality from all causes, cardiovascular disease, and cancer. Med Sci Sports Exerc 2009; 41: 998-1005.
126.
Dunstan DW, Barr EL, Healy GN, et al. Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Circulation 2010; 121: 384-91.
127.
Mayer-Davis EJ, Dabelea D, Lawrence JM. Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med 2017; 377: 301.
128.
Santos-Parker JR, LaRocca TJ, Seals DR. Aerobic exercise and other healthy lifestyle factors that influence vascular aging. Adv Physiol Educ 2014; 38: 296-307.
129.
Stewart LK, Flynn MG, Campbell WW, et al. The influence of exercise training on inflammatory cytokines and C-reactive protein. Med Sci Sports Exerc 2007; 39: 1714-9.
130.
Lavie CJ, Ozemek C, Carbone S, Katzmarzyk PT, Blair SN. Sedentary behavior, exercise, and cardiovascular health. Circ Res 2019; 124: 799-815.
131.
Harber MP, Kaminsky LA, Arena R, et al. Impact of cardiorespiratory fitness on all-cause and disease-specific mortality: advances since 2009. Prog Cardiovasc Dis 2017; 60: 11-20.
132.
Lloyd-Jones DM, Allen NB, Anderson CAM, et al. Life’s essential 8: updating and enhancing the American Heart Association’s Construct of Cardiovascular Health: a presidential advisory from the American Heart Association. Circulation 2022; 146: e18-43.
133.
Gallicchio L, Kalesan B. Sleep duration and mortality: a systematic review and meta-analysis. J Sleep Res 2009; 18: 148-58.
134.
Grandner MA, Hale L, Moore M, Patel NP. Mortality associated with short sleep duration: the evidence, the possible mechanisms, and the future. Sleep Med Rev 2010; 14: 191-203.
136.
Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107: 499-511.
137.
Cappuccio FP, Stranges S, Kandala NB, et al. Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study. Hypertension 2007; 50: 693-700.
138.
Li J, Cao D, Huang Y, et al. Sleep duration and health outcomes: an umbrella review. Sleep Breath 2022; 26: 1479-501.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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