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STATE OF THE ART PAPER
Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways
1
Institute of Health Sciences, Cukurova University, Adana,Turkey
2
Adanus Women’s Health Research Group, Cukurova University, Adana,Turkey
3
Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University, Adana, Turkey
4
Department of Histology and Embryology, Faculty of Medicine, Cukurova University, Adana, Turkey
Submission date: 2023-12-07
Final revision date: 2024-01-16
Acceptance date: 2024-02-20
Online publication date: 2024-12-13
Corresponding author
Ayse Nur Cakir Gungor
Department of Obstetrics and Gynecology Faculty of Medicine Cukurova University Adana, Turkey
Department of Obstetrics and Gynecology Faculty of Medicine Cukurova University Adana, Turkey
KEYWORDS
TOPICS
ABSTRACT
The use of chemotherapeutic agents during childhood, adolescence, and early adulthood has a detrimental effect on ovarian functions, leading to a decrease in ovarian reserves, thus adversely affecting fertility. Alkylating agents are one of the most frequently used groups of chemotherapeutics in this age group. An important and effective chemotherapeutic drug, procarbazine is used to treat brain tumors and Hodgkin lymphoma in children, adolescents, and young adults. This agent is also an indispensable component of combination-type chemotherapy. Procarbazine has a detrimental impact on ovarian reserve by directly targeting the oocyte or indirectly through somatic cell destruction. Evidence gathered thus far indicates that procarbazine’s mode of action in the ovaries may involve apoptosis, inflammation, and oxidative stress. This review seeks to clarify the processes by which procarbazine might induce apoptosis, inflammation, and oxidative stress, hence affecting ovarian reserve and functioning.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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