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CLINICAL RESEARCH
Novel biotargets of colorectal cancer peritoneal metastasis
1
Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China
2
Hangzhou Hospital and Institute of Digestive Diseases, Hangzhou, Zhejiang, China
3
Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, Zhejiang, China
4
Department of Radiotherapy, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
5
Beijing Etown Academy, Beijing, China
Submission date: 2023-08-16
Final revision date: 2023-09-22
Acceptance date: 2023-10-17
Online publication date: 2024-12-20
Corresponding author
Xiaofeng Zhang
Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine Hangzhou, Zhejiang 310006, China, Phone: +86-0571-56006782
Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine Hangzhou, Zhejiang 310006, China, Phone: +86-0571-56006782
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Peritoneal metastasis often predicts advanced progression and a poor prognosis in colorectal cancer (CRC). However, peritoneal metastases are extremely difficult to predict or diagnose by routine diagnostic methods.
Material and methods:
In this study, a microarray containing 30 samples from peritoneal metastasis and their matched CRC primaries obtained during cytoreductive surgery were compared to take a long hard look at all the options on the significant differentially expressed genes. The potential interactions and mechanisms of these expressed genes in promoting peritoneal metastasis were analyzed and studied by multiple bioinformatics analysis.
Results:
The results suggested that the functions of these genes are closely related to immune response and cytokine activity. Additionally, the top 10 core genes’ correction with the leukocyte infiltration and serum cytokine profiles were identified and may be expected to become diagnostic and therapeutic targets of peritoneal metastasis in CRC.
Conclusions:
The expression of IL-6, IL-10 and IL-17 in plasma and their correlation with leukocyte infiltration are proven potential diagnostic, prognostic, and therapeutic biomarkers for peritoneal management of CRC.
Peritoneal metastasis often predicts advanced progression and a poor prognosis in colorectal cancer (CRC). However, peritoneal metastases are extremely difficult to predict or diagnose by routine diagnostic methods.
Material and methods:
In this study, a microarray containing 30 samples from peritoneal metastasis and their matched CRC primaries obtained during cytoreductive surgery were compared to take a long hard look at all the options on the significant differentially expressed genes. The potential interactions and mechanisms of these expressed genes in promoting peritoneal metastasis were analyzed and studied by multiple bioinformatics analysis.
Results:
The results suggested that the functions of these genes are closely related to immune response and cytokine activity. Additionally, the top 10 core genes’ correction with the leukocyte infiltration and serum cytokine profiles were identified and may be expected to become diagnostic and therapeutic targets of peritoneal metastasis in CRC.
Conclusions:
The expression of IL-6, IL-10 and IL-17 in plasma and their correlation with leukocyte infiltration are proven potential diagnostic, prognostic, and therapeutic biomarkers for peritoneal management of CRC.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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