In patients with protein C deficiency, oral anticoagulant therapy with warfarin may cause severe skin necrosis known as warfarin induced skin necrosis(WISN). We present a young female patient of PPCM with protein C deficiency and WISN, warfarin was reintroduced and no skin necrosis occured again. Our case serves to alert physicians for prompt investigation of possible underlying thrombophilia in PPCM patients presented with multiple intracardiac thrombi and unexplained skin lesion. Successful readministration of warfarin in patients with a history of WISN is possible by starting at a low dose with gradual dose adjustment as demonstrated in our case.