Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by a thrombophilic state with pregnancy complications and the presence of circulating antiphospholipid (aPL) antibodies. This syndrome rarely may present with rapidly recurring thrombotic events involving predominantly small vessels of many organs; this presentation is defined as catastrophic APS or Asherson’s syndrome. We report a case of a woman with multi-systemic dysfunction consisting of cerebral symptoms, cardio-pulmonary disease, and renal insufficiency who tested positive for aPL antibodies and factor V Leiden variant.