Introduction:
An eco-friendly biosynthesized FeNP immobilized Coriandrum sativum extract has been introduced.

Material and methods:
The as-prepared nanoparticles (FeNPs) were characterized using UV-Vis, SEM, and FT-IR. It was shown that the iron nanoparticles have spherical shape and uniform size.

Results:
The synthesized nanoparticles have very low cell viability and high anti-liver cancer activities dose-dependently against pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), Morris hepatoma (McA-RH7777), and Novikoff hepatoma (N1-S1 Fudr) cell lines without any cytotoxicity on the normal cell line (HUVEC). The synthesized nanoparticles inhibited half of the DPPH molecules in the concentration of 132 µg/ml. Perhaps notable anti-liver cancer activities of the synthesized nanoparticles against common liver cancer cell lines are linked to their antioxidant activities.

Conclusions:
Our results show that the FeNPs from Coriandrum sativum extract are apposite stabilizing agents, which serve as an effective anticancer agent against liver cancer cell lines.