Humans still suffer from several nervous system diseases affecting perception and body movement, such as Alzheimer's and Parkinson's diseases (PD). PD is a common disease of the nervous system worldwide that is characterized by neurodegenerative movement disorders. There are some indications that the occurrence of oxidative stress and mitochondrial dysfunction are among the main and obvious causes of PD. Parkinson's patients are still dependent on taking levodopa drug, although it has several side effects. Therefore, many scientists and pharmacologists are striving to find a potential drug that can stop or mitigates this disease. Research initiates to find effective natural substances against PD that can diminish the oxidation process in the nerve cells. Therefore, the aim of conducting this review was to highlight the role of some natural products, in the possibility of protecting neurons and improving their biological functions in the way to develop new therapeutic strategies against PD.