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ATHEROSCLEROSIS / RESEARCH LETTER
Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis
1
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3
Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, Mexico
4
Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar, Qatar
5
Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, United Arab Emirates
6
Medical Research Centre, Sultan Qaboos University, Muscat, Oman
7
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland
8
The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA
9
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
10
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
11
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Submission date: 2024-05-24
Final revision date: 2024-05-29
Acceptance date: 2024-06-03
Online publication date: 2024-06-03
Corresponding author
Amirhossein Sahebkar
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, Vakilabad blvd., 9177948564, Mashhad, Iran
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, Vakilabad blvd., 9177948564, Mashhad, Iran
Arch Med Sci 2024;20(3):997-1001
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.
Methods:
The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.
Results:
In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = –0.507, 95% CI: –2.536, 1.521, p = 0.021).
Conclusions:
Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.
Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.
Methods:
The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.
Results:
In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = –0.507, 95% CI: –2.536, 1.521, p = 0.021).
Conclusions:
Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.
REFERENCES (32)
1.
van Woerden G, Gorter TM, Westenbrink BD, Willems TP, van Veldhuisen DJ, Rienstra M. Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. Eur J Heart Failure 2018; 20: 1559-66.
2.
Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, Wong DTL. Epicardial adipose tissue: far more than a fat depot. Cardiovasc Diagn Ther 2014; 4: 416-29.
3.
Al Zein M, Zein O, Diab R, et al. Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis. Biochem Pharmacol 2023; 218: 115876.
4.
Banach M, Reiner Z, Cicero AFG, et al. The year in cardiovascular disease – the year of upfront lipid lowering combination therapy. Arch Med Sci 2022; 18: 1429-34.
5.
Taylor F, Huffman MD, Macedo AF, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013; 2013: CD004816.
6.
Banach M, Surma S. A look to the past – what has had the biggest impact on lipids in the last four decades? A personal perspective. Arch Med Sci 2023; 19: 559-64.
7.
Chamani S, Liberale L, Mobasheri L, et al. The role of statins in the differentiation and function of bone cells. Eur J Clin Invest 2021; 51: e13534.
8.
Vahedian-Azimi A, Beni FH, Fras Z, et al. Effects of statins on the incidence and outcomes of acute kidney injury in critically ill patients: a systematic review and meta-analysis. Arch Med Sci 2023; 19: 952-64.
9.
Vahedian-Azimi A, Mannarino MR, Shojaie S, et al. Effect of statins on prevalence and mortality of influenza virus infection: a systematic review and meta-analysis. Arch Med Sci 2022; 18: 1513-24.
10.
Vahedian-Azimi A, Mohammadi SM, Banach M, et al. Improved COVID-19 outcomes following statin therapy: an updated systematic review and meta-analysis. BioMed Res Int 2021; 2021: 1901772.
11.
Mollazadeh H, Tavana E, Fanni G, et al. Effects of statins on mitochondrial pathways. J Cachexia Sarcopenia Muscle 2021; 12: 237-51.
12.
Sahebkar A, Kiaie N, Gorabi AM, et al. A comprehensive review on the lipid and pleiotropic effects of pitavastatin. Prog Lipid Res 2021; 84: 101127.
13.
German CA, Liao JK. Understanding the molecular mechanisms of statin pleiotropic effects. Arch Toxicol 2023; 97: 1529-45.
14.
Bahrami A, Parsamanesh N, Atkin SL, Banach M, Sahebkar A. Effect of statins on toll-like receptors: a new insight to pleiotropic effects. Pharmacol Res 2018; 135: 230-8.
15.
Fang W, Xie S, Deng W. Epicardial adipose tissue: a potential therapeutic target for cardiovascular diseases J Cardiovasc Transl Res 2024; 17: 322-33.
16.
Raggi P, Gadiyaram V, Zhang C, Chen Z, Lopaschuk G, Stillman AE. Statins reduce epicardial adipose tissue attenuation independent of lipid lowering: a potential pleiotropic effect. J Am Heart Assoc 2019; 8: e013104.
17.
Parisi V, Petraglia L, D’Esposito V, et al. Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue. Int J Cardiol 2019; 274: 326-30.
18.
El Shahawy ES, Hassan AA, El Shahawy MS. Epicardial fat volume as a good predictor for multivessel coronary artery disease. High Blood Press Cardiovasc Prev 2023; 30: 427-34.
19.
Fan W, Si Y, Xing E, et al. Human epicardial adipose tissue inflammation correlates with coronary artery disease. Cytokine 2023; 162: 156119.
20.
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62: 1006-12.
21.
Borenstein M. Comprehensive meta-analysis software. In: Systematic Reviews in Health Research: Meta-analysis in Context. Egger M, Higgins JPT, Davey Smith D (eds.). 2022; 535-48.
22.
Sutton AJ, Abrams KR, Sheldon TA, Song F, Jones DR. Methods for Meta-analysis in Medical Research. Wiley Chichester 2000.
23.
Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration. London, UK 2011.
24.
Kahl K, Kerling A, Tegtbur U, et al. Effects of additional exercise training on epicardial, intra-abdominal and subcutaneous adipose tissue in major depressive disorder: a randomized pilot study. J Affective Disord 2016; 192: 91-7.
25.
Graziani F, Leone AM, Cialdella P, et al. Effects of bariatric surgery on cardiac remodeling: clinical and pathophysiologic implications. Eur Heart J 2013; 34 (Suppl 1): 4356.
26.
Myasoedova VA, Parisi V, Moschetta D, et al. Efficacy of cardiometabolic drugs in reduction of epicardial adipose tissue: a systematic review and meta-analysis. Cardiovasc Diabetol 2023; 22: 23.
27.
Stary HC, Blankenhorn DH, Chandler AB, et al. A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol 1992; 12: 120-34.
28.
Moreno PR, Purushothaman KR, Sirol M, Levy AP, Fuster V. Neovascularization in human atherosclerosis. Circulation 2006; 113: 2245-52.
29.
Takase H, Dohi Y, Okado T, Hashimoto T, Goto Y, Kimura G. Effects of ezetimibe on visceral fat in the metabolic syndrome: a randomised controlled study. Eur J Clin Investig 2012; 42: 1287-94.
30.
Iacobellis G, Sharma AM. Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome. Curr Pharm Design 2007; 13: 2180-4.
31.
Nerlekar N, Thakur U, Lin A, et al. The Natural history of epicardial adipose tissue volume and attenuation: a long-term prospective cohort follow-up study. Sci Rep 2020; 10: 7109.
32.
Soucek F, Covassin N, Singh P, et al. Effects of atorvastatin (80 mg) therapy on quantity of epicardial adipose tissue in patients undergoing pulmonary vein isolation for atrial fibrillation. Am J Cardiol 2015; 116: 1443-6.
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