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RESEARCH LETTER
CSF1 mediating 3-hydroxyhexanoate in endometrial cancer: a Mendelian randomization study
1
Department of Obstetrics and Gynecology, Putuo District Central Hospital, Shanghai Putuo Hospital, Shanghai University of Traditional Chinese Medicine, China
Submission date: 2024-08-12
Final revision date: 2024-09-09
Acceptance date: 2024-09-14
Online publication date: 2024-10-17
Corresponding author
Fan Bozhen
Department of Obstetrics and Gynecology, Putuo District Central Hospital, Shanghai, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, China
Department of Obstetrics and Gynecology, Putuo District Central Hospital, Shanghai, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, China
KEYWORDS
uterine corpus endometrial carcinomaMendelian randomization3-hydroxyhexanoatecolony stimulating factor1
TOPICS
ABSTRACT
Introduction:
This study employed Mendelian randomization (MR) analysis to explore the causal relationship between 3-hydroxyhexanoate and uterine corpus endometrial carcinoma (UCEC), with a focus on the mediating role of colony stimulating factor (CSF1), a chemokine implicated in tumor progression.
Results:
The analysis revealed a negative association between CSF1 and UCEC. Furthermore, the study identified a negative causal link between 3-hydroxyhexanoate and CSF1, suggesting that this metabolite may play a role in the pathogenesis of UCEC.
Conclusions:
The findings suggest that 3-hydroxyhexanoate, through its association with CSF1, could influence the tumor micro-environment of cancer cells, potentially impacting cancer growth and progression.
This study employed Mendelian randomization (MR) analysis to explore the causal relationship between 3-hydroxyhexanoate and uterine corpus endometrial carcinoma (UCEC), with a focus on the mediating role of colony stimulating factor (CSF1), a chemokine implicated in tumor progression.
Results:
The analysis revealed a negative association between CSF1 and UCEC. Furthermore, the study identified a negative causal link between 3-hydroxyhexanoate and CSF1, suggesting that this metabolite may play a role in the pathogenesis of UCEC.
Conclusions:
The findings suggest that 3-hydroxyhexanoate, through its association with CSF1, could influence the tumor micro-environment of cancer cells, potentially impacting cancer growth and progression.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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