NUTRITION / RESEARCH PAPER
Assessing the Impact of Wheat Flour and Baker's Yeast Restricted Diet vs. Calorie Restriction in NAFLD Patients
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Sivas Numune Hospital, Turkey
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Montenegro Primary Health Care Center, Montenegro
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University of Montenegro-Faculty of Medicine, Montenegro
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Erzurum Training and Research Hospital, Turkey
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Department for Medical Biochemistry, University of Belgrade-Faculty of Pharmacy, Serbia
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Giresun University, Turkey
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Batman Training and Research Hospital, Turkey
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Ataturk University, Turkey
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Recep Tayyip Erdogan University, Turkey
Submission date: 2024-07-13
Final revision date: 2024-09-05
Acceptance date: 2024-09-14
Online publication date: 2024-10-26
Corresponding author
Filiz Mercantepe
Recep Tayyip Erdogan University, Recep Tayyip Erdogan Universirty, 53010, Rize, Turkey
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ABSTRACT
Introduction:
Non-alcoholic fatty liver disease (NAFLD) is a prevalent and nonalcoholic progressive liver disorder associated with metabolic disturbance. This study aimed to compare the efficacy of wheat flour or baker's yeast-restricted diet with traditional calorie restriction in NAFLD patients.
Material and methods:
Analyzed data was obtained from 243 individuals with NAFLD who completed the study. Of these patients, 54 belonged to Group (1) (Standard Diet, SD); 104 belonged to Group (2) (Wheat Flour-Free Diet, WFFD); and 85 belonged to Group (3) (Yeast-Free Diet, YFD). The intervention period lasted 6 months, during which participants' dietary compliance was closely monitored.
Results:
At the end of the six-month trial, both the WFFD and HFD groups exhibited a noteworthy reduction in body mass index (BMI) and triglyceride (TG) levels when compared to a standard diet that only involved calorie restriction. Furthermore, a notable reduction in the severity of liver steatosis was seen in these groups (p<0.05). The SD group did not exhibit any significant changes in these metrics. The WFFD group experienced a notable reduction in HSI values (p<0.05). Cluster analysis revealed that the obese group had higher HSI, weight, and BMI values throughout the study period, indicating a more advanced stage of NAFLD.
Conclusions:
To summarize, this study highlights the significance of food constituents and dietary strategies in the treatment of NAFLD. It suggests that limiting the intake of wheat flour and baker's yeast specifically could have positive effects on liver well-being.