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DERMATOLOGY / CLINICAL RESEARCH
A study on the global burden of non-melanoma skin cancer from 1990 to 2019
1
Department of Dermatology, Hangzhou Third People’s Hospital, Hangzhou, China
Submission date: 2024-01-11
Final revision date: 2024-03-22
Acceptance date: 2024-04-09
Online publication date: 2024-04-14
KEYWORDS
TOPICS
ABSTRACT
Introduction:
This study aimed to provide an overview and analysis of the global disease burden of non-melanoma skin cancer using data from the Global Burden of Disease 2019 (GBD 2019) database.
Material and methods:
This study utilized the global GBD 2019 disease data. The data were categorized into various subgroups based on region, sociodemographic index (SDI), country, gender, and age. We analyzed incident cases, incidence rate, disability-adjusted life years (DALYs), DALY rate, as well as age-standardized indicators and their annualized percent change (EAPC).
Results:
The global burden of non-melanoma skin cancer exhibited an increasing trend from 1990 to 2019. The EAPC for the age standardized incidence rate (ASIR) was 1.13, and the EAPC for the age standardized DALY rate was 0.20. Geographic variations were observed, with the most substantial increase in ASIR observed in high-income North America (EAPC: 2.20), and a significant increase in the age standardized DALY rate in Central Asia (EAPC = 2.32). Countries with a high SDI had the highest ASIR and showed the most significant increasing trend (EAPC = 1.97). Overall, the burden of disease for nonmelanoma skin cancer increased in all countries globally from 1990 to 2019. The EAPC for incident cases, DALYs, and ASIR was greater than 0 in almost all countries worldwide, indicating an overall increasing trend.
Conclusions:
The global disease burden of non-melanoma skin cancer ex-hibited significant increasing changes from 1990 to 2019. Several countries in Asia, Africa, and North America experienced a severe disease burden.
This study aimed to provide an overview and analysis of the global disease burden of non-melanoma skin cancer using data from the Global Burden of Disease 2019 (GBD 2019) database.
Material and methods:
This study utilized the global GBD 2019 disease data. The data were categorized into various subgroups based on region, sociodemographic index (SDI), country, gender, and age. We analyzed incident cases, incidence rate, disability-adjusted life years (DALYs), DALY rate, as well as age-standardized indicators and their annualized percent change (EAPC).
Results:
The global burden of non-melanoma skin cancer exhibited an increasing trend from 1990 to 2019. The EAPC for the age standardized incidence rate (ASIR) was 1.13, and the EAPC for the age standardized DALY rate was 0.20. Geographic variations were observed, with the most substantial increase in ASIR observed in high-income North America (EAPC: 2.20), and a significant increase in the age standardized DALY rate in Central Asia (EAPC = 2.32). Countries with a high SDI had the highest ASIR and showed the most significant increasing trend (EAPC = 1.97). Overall, the burden of disease for nonmelanoma skin cancer increased in all countries globally from 1990 to 2019. The EAPC for incident cases, DALYs, and ASIR was greater than 0 in almost all countries worldwide, indicating an overall increasing trend.
Conclusions:
The global disease burden of non-melanoma skin cancer ex-hibited significant increasing changes from 1990 to 2019. Several countries in Asia, Africa, and North America experienced a severe disease burden.
REFERENCES (25)
1.
Khalid A, van Essen P, Crittenden TA, Dean NR. The anatomical distribution of non-melanoma skin cancer: a retrospective cohort study of 22 303 Australian cases. ANZ J Surg 2021; 91: 2750-6.
2.
Hawrot A, Alam M, Ratner D. Squamous cell carcinoma. Curr Problems Dermatol 2003; 15: 91-133.
3.
Ascierto PA, Schadendorf D. Update in the treatment of non-melanoma skin cancers: the use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma. J Immunother Cancer 2022; 10: e005082.
4.
Kalailingam P, Verma A, Lee YH, Thanabalu T. Conditional knockout of N-WASP enhanced the formation of keratinizing squamous cell carcinoma induced by KRas(G12D). Cancers 2023; 15: 4455.
5.
Sapijaszko M, Zloty D, Bourcier M, Poulin Y, Janiszewski P, Ashkenas J. Non-melanoma skin cancer in Canada. Chapter 5: Management of squamous cell carcinoma. J Cutan Med Surg 2015; 19: 249-59.
6.
Lin Y, Fang K, Zheng Y, Wang HL, Wu J. Global burden and trends of neglected tropical diseases from 1990 to 2019. J Travel Med 2022; 29: taac031.
7.
Li Y, He T, Xie J, et al. Trend of human schistosomiasis japonica prevalence in China from 1990 to 2019. Trop Med Infect Dis 2023; 8: 344.
8.
Salomon JA, Vos T, Hogan DR, et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2129-43.
9.
Reichrath J, Reichrath S. The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC): present concepts and future perspectives. Dermatoendocrinol 2013; 5: 38-50.
10.
Durmishi A, Fida M, Hoxha S, et al. Are military personnel at a more risk for skin cancers? Dermatol Ther 2020; 33: e14340.
11.
de Kok IM, van Lenthe FJ, Avendano M, Louwman M, Coebergh JW, Mackenbach JP. Childhood social class and cancer incidence: results of the globe study. Soc Sci Med (1982) 2008; 66: 1131-9.
12.
Ren J, Ceylan-Isik AF. Diabetic cardiomyopathy: do women differ from men? Endocrine 2004; 25: 73-83.
13.
Berger U, Maywald O, Pfirrmann M, et al. Gender aspects in chronic myeloid leukemia: long-term results from randomized studies. Leukemia 2005; 19: 984-9.
14.
Voskuhl RR. Gender issues and multiple sclerosis. Curr Neurol Neurosci Rep 2002; 2: 277-86.
15.
Haupt S, Caramia F, Klein SL, Rubin JB, Haupt Y. Sex disparities matter in cancer development and therapy. Nat Rev Cancer 2021; 21: 393-407.
16.
Shi B, Li W, Song Y, et al. UTX condensation underlies its tumour-suppressive activity. Nature 2021; 597: 726-31.
17.
Liang J, Li X, Kang C, et al. Maternal mortality ratios in 2852 Chinese counties, 1996-2015, and achievement of Millennium Development Goal 5 in China: a subnational analysis of the Global Burden of Disease Study 2016. Lancet (London, England) 2019; 393: 241-52.
18.
Graells J. The risk and risk factors of a second non-melanoma skin cancer: a study in a Mediterranean population. J Eur Acad Dermatol Venereol 2004; 18: 142-7.
19.
Armstrong BK, Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B 2001; 63: 8-18.
20.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin 2022; 72: 7-33.
21.
Aggarwal P, Knabel P, Fleischer AB Jr. United States burden of melanoma and non-melanoma skin cancer from 1990 to 2019. J Am Acad Dermatol 2021; 85: 388-95.
23.
Oh CM, Cho H, Won YJ, et al. Nationwide trends in the incidence of melanoma and non-melanoma skin cancers from 1999 to 2014 in South Korea. Cancer Res Treat 2018; 50: 729-37.
24.
Kim HS, Cho EA, Bae JM, et al. Recent trend in the incidence of premalignant and malignant skin lesions in Korea between 1991 and 2006. J Korean Med Sci 2010; 25: 924-9.
25.
Thet Z, Lam AK, Pham T, et al. Clinical and economic burden of benign and malignant skin lesions in renal transplant recipients. Int Med J 2023; 53: 2042-9.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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