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OTOLARYNGOLOGY / RESEARCH LETTER
A comprehensive analysis of the role of cuproptosis in periodontitis through integrated analysis of single-cell and bulk RNA sequencing
1
Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang, China
2
College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, Shenyang, China
These authors had equal contribution to this work
Submission date: 2024-05-08
Acceptance date: 2024-08-17
Online publication date: 2024-08-29
Publication date: 2024-08-04
Corresponding author
Chuang Guo
College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, shenyang, China
College of Life and Health Sciences, Institute of Neuroscience, Northeastern University, shenyang, China
Arch Med Sci 2024;20(4):1349-1357
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Trace mineral micronutrients are essential for periodontal health, and unbalanced levels of trace minerals are related to chronic periodontitis, including copper. We attempted to explore the relationship between cuproptosis and periodontitis.
Material and methods:
Bulk RNA-seq and single-cell RNA sequencing data were used to analyze expression of cuproptosis-related genes (CRGs) in periodontitis. A mouse periodontitis model was established to verify the expression of key genes.
Results:
Cuproptosis-related genes were differentially expressed in periodontitis. RT-PCR results confirmed the alteration of five key genes in the mouse model.
Conclusions:
Cuproptosis is an important player in the pathophysiological process of periodontitis.
Trace mineral micronutrients are essential for periodontal health, and unbalanced levels of trace minerals are related to chronic periodontitis, including copper. We attempted to explore the relationship between cuproptosis and periodontitis.
Material and methods:
Bulk RNA-seq and single-cell RNA sequencing data were used to analyze expression of cuproptosis-related genes (CRGs) in periodontitis. A mouse periodontitis model was established to verify the expression of key genes.
Results:
Cuproptosis-related genes were differentially expressed in periodontitis. RT-PCR results confirmed the alteration of five key genes in the mouse model.
Conclusions:
Cuproptosis is an important player in the pathophysiological process of periodontitis.
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| eISSN: | 1896-9151 |
| ISSN: | 1734-1922 |
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